Dose-response relationships for resetting of human circadian clock by light
- PMID: 8596632
- DOI: 10.1038/379540a0
Dose-response relationships for resetting of human circadian clock by light
Abstract
Since the first report in unicells, studies across diverse species have demonstrated that light is a powerful synchronizer which resets, in an intensity-dependent manner, endogenous circadian pacemakers. Although it is recognized that bright light (approximately 7,000 to 13,000 lux) is an effective circadian synchronizer in humans, it is widely believed that the human circadian pacemaker is insensitive to ordinary indoor illumination (approximately 50-300 lux). It has been proposed that the relationship between the resetting effect of light and its intensity follows a compressive nonlinear function, such that exposure to lower illuminances still exerts a robust effect. We therefore undertook a series of experiments which support this hypothesis and report here that light of even relatively low intensity (approximately 180 lux) significantly phase-shifts the human circadian pacemaker. Our results clearly demonstrate that humans are much more sensitive to light than initially suspected and support the conclusion that they are not qualitatively different from other mammals in their mechanism of circadian entrainment.
Similar articles
-
Sensitivity of the human circadian pacemaker to moderately bright light.J Biol Rhythms. 1994 Winter;9(3-4):315-31. doi: 10.1177/074873049400900311. J Biol Rhythms. 1994. PMID: 7772798
-
Light-induced suppression of endogenous circadian amplitude in humans.Nature. 1991 Mar 7;350(6313):59-62. doi: 10.1038/350059a0. Nature. 1991. PMID: 2002845
-
Circadian effects of light no brighter than moonlight.J Biol Rhythms. 2007 Aug;22(4):356-67. doi: 10.1177/0748730407301988. J Biol Rhythms. 2007. PMID: 17660452
-
Sleep and circadian rhythms in humans.Cold Spring Harb Symp Quant Biol. 2007;72:579-97. doi: 10.1101/sqb.2007.72.064. Cold Spring Harb Symp Quant Biol. 2007. PMID: 18419318 Review.
-
The effect of light on the human circadian pacemaker.Ciba Found Symp. 1995;183:254-90; discussion 290-302. doi: 10.1002/9780470514597.ch14. Ciba Found Symp. 1995. PMID: 7656689 Review.
Cited by
-
Towards an evidence-based integrative lighting score: a proposed multi-level approach.Ann Med. 2024 Dec;56(1):2381220. doi: 10.1080/07853890.2024.2381220. Epub 2024 Jul 25. Ann Med. 2024. PMID: 39049780 Free PMC article. Review.
-
Midpoint of sleep is associated with sleep quality in older adults with and without symptomatic Alzheimer's disease.Sleep Adv. 2024 Apr 15;5(1):zpae023. doi: 10.1093/sleepadvances/zpae023. eCollection 2024. Sleep Adv. 2024. PMID: 38711547 Free PMC article.
-
Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression.Toxics. 2024 Jan 26;12(2):106. doi: 10.3390/toxics12020106. Toxics. 2024. PMID: 38393201 Free PMC article.
-
A perspective on the Festschrift of Charles A. Czeisler, PhD MD.Sleep Health. 2024 Feb;10(1S):S4-S10. doi: 10.1016/j.sleh.2024.01.003. Epub 2024 Feb 7. Sleep Health. 2024. PMID: 38331654 No abstract available.
-
Hybrid effectiveness-implementation study of two novel spectrally engineered lighting interventions for shiftworkers on a high-security watchfloor.Sleep Adv. 2023 Nov 21;4(1):zpad051. doi: 10.1093/sleepadvances/zpad051. eCollection 2023. Sleep Adv. 2023. PMID: 38084298 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources