A person receiving sound therapy through headphones and electrical stimulation on their tongue

Combining sound with tongue stimulation for the treatment of tinnitus

Michael Boedts and colleagues report positive efficacy and safety results of a nonsurgical treatment for tinnitus, using a device that combines sound therapy with electrical tongue stimulation.

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  • Ocean energy extraction is on the rise, but complex flows still challenge reliable tidal stream energy generation. Here, using aerial drones and boat-based surveys, authors map out the turbulent flows around an idled, utility-scale floating tidal turbine.

    • Lilian Lieber
    • Shaun Fraser
    • W. Alex M. Nimmo-Smith
    ArticleOpen Access
  • Simultaneously converting plastic waste and CO2 into value-added chemicals remains a challenge. Here, the authors demonstrate the feasibility of transforming waste plastics and CO2 into H2 and CO by utilizing solar irradiation via a photovoltaic system and an electrified FeCrAl heating wire.

    • Qing Ma
    • Yongjun Gao
    • Ding Ma
    ArticleOpen Access
  • The authors present an exciting 3D meta-holography based on angular spectrum diffraction theory that significantly improves depth limits. The showcased amorphous silicon metasurface with independent polarization control herein achieves a 47.5x depth increase and 0.95 dm depth reconstructions for polarization-independent and different color 3D meta-hologram.

    • Di Wang
    • Yi-Long Li
    • Qiong-Hua Wang
    ArticleOpen Access
  • Metastable water, when dynamically over-compressed, freezes into ice VII. Here the authors present a dynamic diamond anvil cell (d-DAC) study that unifies data acquired across multiple platforms, explaining the solidification pressure evolution under varying compression rates using classical nucleation theory.

    • Charles M. Pépin
    • Ramesh André
    • Paul Loubeyre
    ArticleOpen Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

  • New molecular technologies have helped unveil facets of the genome beyond the canonical proteome, such as microproteins and short ORFs, products of alternative splicing, regulatory non-coding RNAs, transposable elements, and cis-regulatory DNA. In this Review, Gervais & Shapiro highlight what is known about this ‘hidden genome’ in fungi.

    • Nicholas C. Gervais
    • Rebecca S. Shapiro
    Review ArticleOpen Access
  • Parkin is a ubiquitin ligase that protects against early-onset Parkinson’s disease. Here, the authors show a molecular glue that promotes binding of phosphorylated ubiquitin to parkin and rescues the mitophagy defect of mutations in the parkin ubiquitin-like domain.

    • Véronique Sauvé
    • Eric Stefan
    • Kalle Gehring
    ArticleOpen Access
  • The authors introduce STANDS, a GAN-based framework that integrates three core tasks for the multi-sample detection and dissection of anomalous tissue domains from spatial transcriptomics data, revealing pathogenic heterogeneity behind diseases.

    • Kaichen Xu
    • Yan Lu
    • Xiaobo Sun
    ArticleOpen Access
  • How the brain sequentially encodes knowledge is not fully understood. Here authors propose a geometric framework for the elusive neural principles of serial reasoning and sequence encoding. Neural representations are theorized to align along a learned mental line, solving serial position and transitive inference tasks.

    • Gabriele Di Antonio
    • Sofia Raglio
    • Maurizio Mattia
    ArticleOpen Access

Subjects within Biological sciences

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  • Compressing global energy and industrial system decarbonization into less than three decades creates unique social, technical, financial and political risks. Here we introduce ‘off-ramps’ as one potential approach to manage these whilst still driving rapid emissions reductions.

    • Sam Uden
    • Chris Greig
    CommentOpen Access
  • Plant nitrogen source in the soil is challenging to track. Compiling the most comprehensive global δ15N dataset, a new study shows the plant use of various available soil nitrogen forms (ammonium, nitrate, and organic nitrogen) is strongly controlled by temperature.

    • Lixin Wang
    CommentOpen Access
  • Liang et al. present an industrial perspective on the evolving landscape of laser technology used in advanced LiDAR systems. The authors discuss recent trends, practical considerations within the industry, current challenges, and potential solutions, explicitly focusing on VCSEL/AR-VCSEL-based technologies and their strong potential for commercial LiDAR applications.

    • Dong Liang
    • Cheng Zhang
    • Yijie Huo
    CommentOpen Access
  • Neuronal activity consumes cellular energy and generates carbon dioxide (CO2). To counter this metabolic challenge, synaptic signalling communicates with nearby microvasculature to increase local blood flow. Is this process solely based on feedforward synaptic signalling, or is the generated CO2 also involved? This question was addressed in mice in a new Nature Communications publication by Tournissac and colleagues where they showed that neurovascular coupling is not affected by exogenous CO2 or its associated acidification.

    • Grant R. Gordon
    CommentOpen Access
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On this page, we highlight some of our most exciting recently published articles in the areas of biochemistry, biophysics, mass spectrometry and structural biology as well as related methodology papers.
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